Redish et al. rely too much on a rational and innate view of decision-making, when their emphasis on variation, their integrative spirit, and their neuroscientific insights point towards a broader view of why addiction is such a tenacious problem. The integration of subjective, sociocultural, and evolutionary factors with cognitive neuroscience advances our understanding of addiction and decision-making.

Müller & Schumann (M&S) deserve applause for their interdisciplinary examination of drug use, evolution, and learning. Further steps can deepen their evolutionary analysis: a focus on adaptive benefits, a distinction between approach and consummatory behaviors, an examination of how drugs can create adaptive lag through changing human niche construction, the importance of other neurobehavioral mechanisms in drug use besides instrumentalization, and the importance of sociocultural dynamics and neural plasticity in both human evolution and drug use.